CREB相关论文
目的:观察疏肝健脾清热方对功能性消化不良（FD）模型大鼠胃黏膜组织五羟色胺1A（5-HT1A）受体及环磷腺苷效应元件结合蛋白（CREB）表达的影响,......
背景与目的以慢性高血糖为特征的2型糖尿病在全球范围内呈流行态势,严重危害人类健康。肝脏糖异生是参与维持机体血糖稳态的重要代......
近年来,结直肠癌（colorectalcancer,CRC）的死亡率已经位居全球恶性肿瘤的第四位,而且发病率还在不断攀升。结直肠癌早期发病症状隐匿......
目的:胰腺癌恶性程度高、起病隐匿、进展快、预后差,至今胰腺癌发生、发展的具体机制尚不清楚。我们前期对临床样本（胰腺导管腺癌组......
学位
钩吻（G.elegans）为马钱科胡蔓藤属的毒性植物,在传统药物学上,主要用于治疗各种治疗各种焦虑和神经疼痛等方面的疾病。钩吻所含成分......
CREB是一种重要的核转录调控因子,为bZIP家族成员之一。它的单体从N端到C端主要包括激酶诱导域（KID）、碱性区（basic region）和亮氨酸拉......
目的:探究藏红花素对孤独症模型鼠学习记忆及海马神经元数量、脑源性神经营养因子（brain-derived neurotrophicor,BDNF）、环磷酸腺苷......
目的:研究磷酸三苯酯（TPHP）暴露对大鼠的焦虑和抑郁样神经毒性作用及其作用机制。方法:雄性和雌性SD大鼠各52只,随机分为4组,分别为......
白内障是全球首要的致盲眼疾。目前对于白内障的治疗手段主要是通过手术移植,但术后并发症如晶状体囊膜混浊给病人带来视力下降和......
目的:观察氟西汀联合毛蕊花糖苷(Act)对抑郁症大鼠CREB表达、学习记忆能力的影响.方法:将SD大鼠随机分为对照组(健康大鼠)、模型组......
目的:探讨miR-383-3p对鼻咽癌6-10B细胞功能的影响及其可能作用的靶基因。方法:采用脂质体介导法将miR-383-3p模拟物（miR-383-3p mi......
目的:研究推拿对CCI模型大鼠脊髓背角NMDA受体介导的下游CaMKⅡ和CREB表达的影响.方法:将40只SD大鼠平均分为5组,分别为空白组、模......
目的探讨化浊解毒疏肝方（HJSF）对慢性不可预知温和刺激（CUMS）模型小鼠行为学及细胞外调节蛋白激酶（ERK）、环磷腺苷效应元件结合蛋白（CREB）......
抑郁症是一种常见的神经系统疾病。据统计,全世界有超过3亿人口受到抑郁症的影响。抑郁症的核心症状包括情绪低落、快感缺失、对日......
目的观察补中益气安神汤（BZYQAS）对脾虚证失眠脑肠轴CREB/BDNF/TrkB信号通路的影响。方法将大鼠随机分为8组:正常组,模型组,百乐眠组......
目的:癫痫是一种常见的神经系统疾病。c AMP反应元件结合蛋白（c AMP response element binding protein,CREB）和苔藓纤维出芽（mossy f......
目的：观察鸡血藤总黄酮的抗抑郁作用，并探讨其作用机制。方法：KM小鼠随机分为空白组，鸡血藤总黄酮高、中、低剂量组(1、0.5、0.25g·kg......
细胞色素P450（cytochromeP450,CYP）超家族酶系,参与内、外源性物质的代谢、失活及活化。CYP超家族酶系主要表达在肝脏,但近年来的研......
昆虫取食行为指昆虫在摄取食物时所发生的一系列活动,一般昆虫个体的取食行为不仅能够表现出种群的相似性也会表现出种群独有的固......
研究背景卵巢癌（Ovarian cancer）是常见的妇科肿瘤。卵巢恶性肿瘤是女性生殖器常见的三大恶性肿瘤之一[1]。由于卵巢位于盆腔深部,早......
目的:帕金森病（Parkinson’s disease,PD）是由中脑黑质致密部及纹状体部位的多巴胺能神经元病变引起的一种神经退行性疾病。虽然PD的......
第一部分:成年哺乳动物中枢神经系统损伤后难以再生,是困扰神经科学界的百年难题和当代神经科学研究的一个前沿问题。近年来人们认......
Gait analysis combined with the expression of TGF-β1, TGF-β3 and CREB during Achilles tendon healing
Purpose::To observe the changes of gait behavior and the expression of wound healing factors of transforming growth fact......
目的 观察补精益视片对SD大鼠慢性高眼压(elevated intraocular pressure,EIOP)模型外侧膝状体(lateral geniculate nucleus,LGN)......
恐惧位于记忆和情感的交汇处,既是触发防御机制以适应危险的一种情绪反应,又是研究记忆的模型.恐惧调节障碍时常会导致焦虑.该文综......
研究目的:常染色体显性多囊肾病（ADPKD）是最常见的遗传性肾病,也是导致终末期肾病的主要因素之一。多囊肾病的主要表现为双侧肾囊肿......
草乌甲素是从云南滇西特有药用植物滇西嘟啦中分离出来的乌头属植物生物碱,属于现代植物药,具有抗炎、镇痛及免疫调节作用。草乌甲......
The steroid hormone 1,25-dihydroxy vitamin D3 [1α,25-(OH)2D3] plays a key role in calcium homeostasis and bone metaboli......
目的 三阴性乳腺癌由于缺乏有效的治疗靶点而易于复发和发生远端转移，正在威胁着女性的生命安全。因此，迫切需要开发出针对三阴性乳......
胶质细胞系源性神经营养因子(glial cell line-derived neurotrophic factor,GDNF)基因在胶质瘤细胞中异常高转录与其启动子Ⅱ区甲......
Objective Social defeat stress(SDS)induces social avoidance and anxiety-like phenotypes....
Overexpression of CEP72 Promotes Bladder Urothelial Carcinoma Cell Aggressiveness via Epigenetic CRE
Objective Urothelial carcinoma of the bladder(UCB)is one of the most common and lethal urothelial malignancies if not tr......
Objective: It is now widely accepted that mitochondrial calcium homeostasis and mitochondrial biogenesis plays a series ......
TORC1 controls the kinetics of CRE-target gene transcription and dendritic growth of developing cort
Activity-dependent CREB-target gene transcription is implicated in cortical dendritic development.However,the molecular ......
Neuronal nitric oxide synthase alteration accounts for the role of 5-HT1A-receptor in modulating anx
Objection Epidemiological studies of anxiety disorders have indicated that as many as 29% of people will, at some point ......
目的 考察临床上起效时间有明显区别的两种药物氟西汀及艾司西酞普兰不同的使用时程对大鼠抑郁样行为及海马CREB、BDNF两种基因表......
Aim Fragile X mental retardation protein (FMRP) is an RNAbinding protein important for the control of translation and sy......
β-amyloid (Aβ) deposition is considered to be partly responsible for cognitive dysfunction in Alzheimers disease (AD).......
目的 探讨补虚化瘀方药参归仁合剂对产后抑郁PPD 大鼠模型雌激素E2 水平,额叶环磷腺苷反应元件结合蛋白CREB,细胞外调节蛋白激酶ER......
Our previous data showed that differentiated adipocyte has higher Tshr protein and mRNA expression level than the preadi......
Roflupram, a PDE4 inhibitor, recues cognitive dysfunction in APP/PS1 transgenic mice via cAMP/PKA/CR
Background: So far,no PDE4 inhibitors in Alzheimers disease has been approved for application in the clinic due to sever......
TNFAIP1 was originally identified as a tumor necrosis factor alpha(TNFα)-induced protein involvesd in DNA replication,D......
目的 探讨环腺苷酸应答元件结合蛋白(cAMP response element binding protein,CREB)/脑源性神经生长因子(brain derived neurotrop......
The neuropeptide substance P (SP) has been found to possibly regulate natural killer(NK) cell activities.However, the mo......
δ-Opioid receptor activation reduce hypoxia-and MPP+-induced α-synuclein overexpression and oligomer
We have previously demonstrated that δ-Opioid receptor (DOR) plays a crucial role in neuroprotection under both normoxi......
